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Friday, July 24, 2020 | History

1 edition of ADP-Ribosylating toxins and G proteins found in the catalog.

ADP-Ribosylating toxins and G proteins

ADP-Ribosylating toxins and G proteins

insights into signal transduction

  • 194 Want to read
  • 12 Currently reading

Published by American Society for Microbiology in Washington, D.C .
Written in English

    Subjects:
  • Bacterial toxins -- Physiological effect.,
  • G proteins -- Physiological effect.,
  • Cellular signal transduction.,
  • ADP-ribosylation.,
  • Guanine nucleotide regulatory protein.,
  • Poly ADP ribose polymerase.

  • Edition Notes

    Includes bibliographical references and index.

    Statementedited by Joel Moss and Martha Vaughan.
    ContributionsMoss, Joel., Vaughan, Martha, 1926-, American Society for Microbiology.
    ID Numbers
    Open LibraryOL19210839M

    ADP ribosylation factors (ARFs) are members of the ARF family of GTP-binding proteins of the Ras family proteins are ubiquitous in eukaryotic cells, and six highly conserved members of the family have been identified in mammalian cells. Although ARFs are soluble, they generally associate with membranes because of N-terminus ro: IPR Bacterial protein toxins play an important role in infectious diseases. Several are highly potent human poisons, such as botulinum, tetanus, Shiga, and diphtheria toxins. These toxins are multi-functional proteins that are self-programmed to reach their target organs and/or enter cells.

    Computer analysis of the three‐dimensional structure of ADP‐ribosylating toxins showed that in all toxins the NAD‐binding site is located in a cavity. This cavity consists of 16 contiguous amino acids that form an a‐helix bent over β‐strand. The tertiary folding of this structure . The Comprehensive Sourcebook of Bacterial Protein Toxins, Fourth Edition, contains chapters written by internationally known and well-respected book contains chapters devoted to individual toxins, as well as chapters that consider the different applications of these toxins.

    Online shopping from a great selection at Books Store. Books Advanced Search New Releases Amazon Charts Best Sellers & More The New York Times® Best Sellers Children's Books Textbooks Textbook Rentals Sell Us Your Books Best Books of the Month Kindle eBooks. usage. Seven toxins or toxin families are covered by this volume. These include the "classical" G-protein-ADP-ribosylating toxins chol- era toxin and pertussis toxin, which are established tools to study sig- nal transduction processes (chapters ). Properties and application.


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ADP-Ribosylating toxins and G proteins Download PDF EPUB FB2

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Second, the ADP-ribosylating toxins provide potent and often unique pharmacological tools for the study of the physiological functions of their target proteins. The latter is especially the case with cholera and pertussis toxins, which both modify the IX-subunits of heterotrimeric G-proteins involved in signal transduction pathways.

Additional Physical Format: Online version: ADP-ribosylating toxins and G proteins. Washington, D.C.: American Society for Microbiology, © xviii, p.: 26 cmPages:   Second, the ADP-ribosylating toxins provide potent and often unique pharmacological tools for the study of the physiological functions of their target proteins.

The latter is especially the case with cholera and pertussis toxins, which both modify the IX-subunits of heterotrimeric G-proteins involved in signal transduction pathways. Pathogenic bacteria utilize a variety of virulence factors that contribute to the clinical manifestation of their pathogenesis.

Bacterial ADP-ribosylating exotoxins (bAREs) represent one family of virulence factors that exert their toxic effects by transferring the ADP-ribose moiety of Cited by: Delphine Quénet, in International Review of Cell and Molecular Biology, ADP-Ribosylation.

ADP-ribosylation is a reaction catalyzed by most of members of the poly(ADP-ribose) polymerase (PARP) family, that is composed of 17 proteins in human (Barkauskaite et al., ).With the exception of PARP9 and PARP13, PARP proteins ADP-Ribosylating toxins and G proteins book a single mono-ADP-ribose group from NAD + to their.

A.D.P.-Ribosylating Toxins (Current Topics in Microbiology and Immunology) [Aktories, Klaus] on *FREE* shipping on qualifying offers. A.D.P.-Ribosylating Toxins (Current Topics in Microbiology and Immunology). This book reviews recent studies on ADP-ribosylating bacterial toxins.

Sevenchapters cover the basic actions of diphtheria toxin, Pseudomonas aeruginosaexotoxins A and S, cholera toxin, pertussis toxin and clostridial ADP-ribosylating toxins.

The cellular entry mechanisms of the toxins are reviewed. Abstract. Several ADP-ribosylating toxins, such as cholera toxin, pertussis toxin, diphtheria toxin, and Pseudomonas aeruginosa exotoxin A have been the focus of intensive research for many years.

Studies on these toxins, which are described in other chapters of this volume, have brought about insights into the pathogenetic mechanisms of diseases related to the toxin-producing by: These toxins' targets are often crucial switch proteins of cellular signaling like heterotrimeric G proteins.

For example, this is true for the activation of the G s proteins, which are ADP-ribosylated by cholera toxin, and also for the Gi proteins, which are inhibited by pertussis toxin-catalyzed ADP-ribosylation.

ADP-Ribosylating Toxins by Klaus Aktories,available at Book Depository with free delivery : Klaus Aktories. Molecular mechanisms of the cytotoxicity of ADP-ribosylating toxins.

Deng Q(1), Barbieri JT. Author information: (1)Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, WisconsinUSA. [email protected] Bacterial pathogens utilize toxins to Cited by: These proteins possess a single (A-domain) that modifies Rho proteins.

In contrast, C2-like toxins require a binding/translocation partner (B-component) for intoxication. These are A-only toxins that contain the E-x-E motif, modify G-actin, but are two-domains with a C-domain possessing enzymatic activity.

Here, we characterized the actin ADP-ribosyltransferase CDTa from C. difficile. CDT is a member of the iota family of binary ADP-ribosylating toxins, which also includes iota toxin from C Author: Michel Popoff. Since the target proteins of ADP-ribosylating toxins are all located in the cytosol or in the inner face of the cytoplasmic membrane, the toxins need to cross the cell membrane in order to reach.

Toxins and Cellular Signals. (Book Reviews: ADP-Ribosylating Toxins and G Proteins. Insights into Signal Transduction.)Author: Henry R. Bourne. The study of ADP-ribosylating toxins has advanced our understanding of bacterial pathogenesis and provided insight into the molecular basis of eukaryotic physiology, especially G-protein-coupled signal transduction.

The pathology associated with an ADP-ribosylating toxin is due to alterations in the activity of specific eukaryotic proteins. To date, essentially all of the eukaryotic proteins Cited by: 3.

@article{osti_, title = {ADP-ribosylation of proteins: Enzymology and biological significance}, author = {Althaus, F.R. and Richter, C.}, abstractNote = {This book presents an overview of the molecular and biological consequences of the posttranslational modification of proteins with ADP-ribose monomers and polymers.

Part one focuses on chromatin-associated poly ADP-ribosylation. The study of ADP-ribosylating toxins has advanced our understanding of bacterial pathogenesis and provided insight into the molecular basis of eukaryotic physiology, especially G-protein-coupled signal transduction. The pathology associated with an ADP-ribosylating toxin is due to alterations in the activity of specific eukaryotic proteins.

Targeted delivery of an ADP-ribosylating bacterial toxin into cancer cells The Harvard community has made this Some bacterial toxins are composed of two separate proteins: a pore-forming transport unit and a catalytic 1.

(() Targeted delivery of an ADP-ribosylating bacterial toxin into cancer.Once inside the cell the A-protomer ribosylates specific target proteins such as the α subunit of heterotrimeric Gi/o proteins (Figure 2) through its ADP-ribosyltransferase activity.

ADP-ribosylation is also responsible for the actions of other bacterial ADP-ribosylating toxins, such as cholera toxin, diphtheria toxin, and exotoxin [email protected]{osti_, title = {Cholix Toxin, a Novel ADP-ribosylating Factor from Vibrio cholerae}, author = {Jorgensen, Rene and Purdy, Alexandra E and Fieldhouse, Robert J and Kimber, Matthew S and Bartlett, Douglas H and Merrill, A Rod and NIH) and UCSD)}, abstractNote = {The ADP-ribosyltransferases are a class of enzymes that display activity in a variety of bacterial pathogens.